I'm surprised by some of these - The Pretender, in particular. I was just talking about how obsessed I was with that show and everyone in the group had no idea what I was talking about. But I can't really think of any other show that took place in Delaware.
Edit: changed from "most popular" to "most significant" as pointed out by bearslovehoney. I wonder what his criteria was because it's somewhat baffling in places. I guess my surprise was valid! Ashronin made their own custom list. I encourage you to do the same.