I was thinking about this because I just happened to hear a Simon & Garfunkel song earlier. For some reason, "American Tune" just...gets me. Every time. Like, tears-in-the-eyes into it, especially if I listen to it at night when it's very quiet. (I think it's the bridge — "my soul rose—"). Maybe I'm a big sap, but I think that most of us must have a song or three like that, right? A song that totally captivates you and pulls at you every time you hear it?
ETA: Probably worth mentioning that my pop used to play this for us all the time when we were kids, so I think no small part of it is that I can, in my head, summon exactly how he sang the bridge.